Raw MRI scans undergo a series of steps that correct for noise including gradient distortion correction and subject motion correction.
With state-of-the-art algorithms, Quicktome automatically eliminates the need for manual tuning in areas of freewater such as edema.
Unlike DTI, CSD is capable of modelling multiple tracts crossing the same region , a phenomenon present in 70% - 90% of white matter . This includes important regions suchs the visual tracts, the language tracts, and the lateral projections of hand-motor.
Using the resultant tractography, a machine-learning-based technique called structural connectivity atlasing (SCA) is applied. SCA determines parcellation locations based on their connections - including in areas where anatomy may have changed due to pathology.
1. Tournier, J. D., Yeh, C. H., Calamante, F., Cho, K. H., Connelly, A., & Lin, C. P. (2008). Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion-weighted imaging phantom data. NeuroImage, 42(2), 617–625. https://doi.org/10.1016/j.neuroimage.2008.05.002
2. Farquharson S, Tournier JD, Calamante F, et al. White matter fiber tractography: why we need to move beyond DTI. J Neurosurg. 2013;118(6):1367‐1377. doi:10.3171/2013.2.JNS121294
3. Alessandro Arrigo, M. D., & Mormina, E. (2016). Diffusion MRI of Human Brain: Key Points and Innovations.